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Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa

Yixin Kang, Lu Xie, Jiyong Yang, Junchang Cui

Frontiers in Cellular and Infection Microbiology · 2023 · 15 citations · 20 references

DOIFull text

Open access

Abstract

AZA has been considered as an option for the treatment of infections caused by XDR/PDR <i>P. aeruginosa</i> producing IMP-45, VIM-1, or VIM-2. OTAT with sufficient pharmacodynamic exposure may be an optimal treatment option for XDR/PDR <i>P. aeruginosa</i> with a high-level MIC of CZA/AZA.

References

20

Characterization of a New Metallo-β-Lactamase Gene, <i>bla</i> <sub>NDM-1</sub> , and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in <i>Klebsiella pneumoniae</i> Sequence Type 14 from India

Dongeun Yong, Mark A. Toleman, Christian G. Giske et al. · Antimicrobial Agents and Chemotherapy · 2009 · 2.4K citations · Full text

, , +19

Pseudomonas Aeruginosa: Resistance to the Max

Keith Poole · Frontiers in Microbiology · 2011 · 922 citations · Full text

, , +18

Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial

Antoní Torres, Nanshan Zhong, Jan Pachl et al. · The Lancet Infectious Diseases · 2017 · 427 citations

, , +5

Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 Program

John E. Mazuski, Leanne B. Gasink, J. Armstrong et al. · Clinical Infectious Diseases · 2016 · 376 citations · Full text

Pseudomonas aeruginosa Antimicrobial Susceptibility Results from Four Years (2012 to 2015) of the International Network for Optimal Resistance Monitoring Program in the United States

Hélio S. Sader, Michael D. Huband, Mariana Castanheira et al. · Antimicrobial Agents and Chemotherapy · 2017 · 136 citations · Full text