Mutant <i>KRAS</i> Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma - Concepedia

Concepedia

Publication | Open Access

Mutant <i>KRAS</i> Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

DOI Full Paper Access

42

Citations

26

References

2023

Year

Yao Kong, Yuming Luo, Shangyou Zheng, Jiabin Yang, Dingwen Zhang, Yue Zhao, Hanhao Zheng, Mingjie An, Yan Lin, Le Ai,

Cancer Research

Abstract

Increased splicing-mediated biogenesis of circARFGEF2 in KRAS-mutant pancreatic ductal adenocarcinoma activates JAK2-STAT3 signaling and triggers lymph node metastasis, suggesting circARFGEF2 could be a therapeutic target to inhibit pancreatic cancer progression.

References

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