Regenerative Biomaterials · 2023 · 10 citations · 36 references
MedicineBioengineeringBiomedical EngineeringBiocompatibilityBiomaterialsTissue EngineeringBone Graft MaterialsBone Matrix CompositionBone TissueBone Tissue EngineeringOsteogenesisSynthetic Bone SubstitutesBiocompatibility Of Regenerative MaterialsBone Matrix Mechanical PropertiesBone Regeneration MaterialsCalcium Sulfate HemihydrateCompressive StrengthDentin Organic MatrixOsteoconductivityOsteoinductive Materials
Abstract It is still a huge challenge for bone regenerative biomaterial to balance its mechanical, biological and biodegradable properties. In the present study, a new composite material including treated dentin matrix (TDM) and α-calcium sulphate hemihydrate (α-CSH) was prepared. The optimal composition ratio between TDM and α-CSH was explored. The results indicate that both components were physically mixed and structurally stable. Its compressive strength reaches up to 5.027 ± 0.035 MPa for 50%TDM/α-CSH group, similar to human cancellous bone tissues. Biological experiments results show that TDM/α-CSH composite exhibits excellent biocompatibility and the expression of osteogenic related genes and proteins (ALP, RUNX2, OPN) is significantly increased. In vivo experiments suggest that the addition of TDM for each group (10%, 30%, 50%) effectively promotes cell proliferation and osteomalacia. In addition, 50% of the TDM/α-CSH combination displays optimal osteoconductivity. The novel TDM/α-CSH composite is a good candidate for certain applications in bone tissue engineering.
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Biomaterials and nanomedicine for bone regeneration: Progress and future prospects
Jun Zhou, Zhongyang Zhang, John Joseph et al. · Exploration · 2021 · 247 citations · Full text