Concepedia

Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial

Bernhards Ogutu, Adoke Yeka, Sylvia Kusemererwa, Ricardo Thompson, Halidou Tinto, André Offianan Touré, Chirapong Uthaisin, Amar Verma, Afizi Kibuuka, Moussa Lingani,

The Lancet Infectious Diseases · 2023 · 40 citations · 10 references

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Open access

Concepts

References

10

Evidence of Artemisinin-Resistant Malaria in Africa

Betty Balikagala, Naoyuki Fukuda, Mie Ikeda et al. · New England Journal of Medicine · 2021 · 938 citations · Full text

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KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

Kelli Kuhen, Arnab K. Chatterjee, Matthias Rottmann et al. · Antimicrobial Agents and Chemotherapy · 2014 · 158 citations · Full text

, , +17

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

Nicholas J. White, Tran Thanh Duong, Chirapong Uthaisin et al. · New England Journal of Medicine · 2016 · 107 citations · Full text

, , +17

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

F. Joel Leong, Rong Zhao, Shuqi Zeng et al. · Antimicrobial Agents and Chemotherapy · 2014 · 66 citations · Full text

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Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Gregory LaMonte, Frances Rocamora, Danushka S. Marapana et al. · Nature Communications · 2020 · 55 citations · Full text

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