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Disseminated fungal infection in a patient receiving zanubrutinib

Madalyn Walsh, Alice Xu, Zuhair K. Ballas, Rolando Sanchez

Clinical Case Reports · 2023 · 14 citations · 4 references

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Abstract

We report a case of fatal disseminated aspergillosis in the setting of administration of zanubrutinib, a second-generation Bruton's tyrosine kinase inhibitor thought to have a lower rate of immunosuppression-related side effects.

References

4

Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL

Constantine S. Tam, Judith Trotman, Stephen Opat et al. · Blood · 2019 · 355 citations · Full text

Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways

Georgios Chamilos, Michail S. Lionakis, Dimitrios P. Kontoyiannis · Clinical Infectious Diseases · 2017 · 260 citations · Full text

Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial

Peter Hillmen, Barbara Eichhorst, Jennifer R. Brown et al. · Journal of Clinical Oncology · 2022 · 89 citations · Full text

Disseminated fungal infection in a patient receiving zanubrutinib

Madalyn Walsh, Alice Xu, Zuhair K. Ballas et al. · Clinical Case Reports · 2023 · 14 citations · Full text

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