Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus,<i>Peroneutypa</i>sp.

Abstract

Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus <i>Peroneutypa</i> sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (<b>1</b>, <b>2</b>, <b>4</b>-<b>8</b>), along with known polyketides (<b>3</b>, <b>9</b>-<b>13</b>). Structures of compounds <b>1</b>, <b>2</b>, and <b>4</b>-<b>8</b> were established by analysis of spectroscopic data. Absolute configurations of compounds <b>1</b>, <b>2</b>, <b>4</b>, <b>6</b>, <b>7</b>, and <b>8</b> were determined by the comparison of experimental ECD spectra with calculated CD data. Compound <b>5</b> exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of <i>Plasmodium falciparum</i>.