Concepedia

Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases

Yunqian Zhu, Mingyu Gan, Mengmeng Ge, Xinran Dong, Gangfeng Yan, Qinhua Zhou, Hui Yu, Xiaochuan Wang, Yun Cao, Guoping Lü,

Journal of Clinical Microbiology · 2023 · 41 citations · 16 references

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Concepts

Abstract

0.001). mNGS is valuable for pathogen detection, diagnosis, and clinical management of infections among pediatric patients. mNGS was thus effective for the diagnosis of pediatric infections, which may guide clinical management. Patients with immunosuppressive conditions benefited more from mNGS testing.

References

16

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Theo Vos, Amanuel Alemu Abajobir, Kalkidan Hassen Abate et al. · The Lancet · 2017 · 13.5K citations · Full text

, , +16

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Scott L. Weiss, Julie C. Fitzgerald, John Pappachan et al. · American Journal of Respiratory and Critical Care Medicine · 2015 · 1K citations

, , +15

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

Michael R. Wilson, Hannah A. Sample, Kelsey C. Zorn et al. · New England Journal of Medicine · 2019 · 1K citations · Full text

, , +15

Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease

Timothy A. Blauwkamp, Simone A. Thair, Michael Rosen et al. · Nature Microbiology · 2019 · 977 citations

, , +11

Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice

Qing Miao, Yuyan Ma, Qingqing Wang et al. · Clinical Infectious Diseases · 2018 · 895 citations · Full text

, , +13