Targeting CDK4/6 in glioblastoma <i>via in situ</i> injection of a cellulose-based hydrogel

Abstract

A cellulose-based hydrogel carrying CDK4/6 inhibitor was developed for the treatment of glioblastoma. It combines Fenton-like reaction and CDK4/6 inhibition to trigger sustained induction of senescence and apoptosis in glioblastoma via in situ injection into the tumor nidus.