In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal–Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy

Abstract

Bacterial-induced infectious diseases have always caused an unavoidable problem and lead to an increasing threat to human health. Hence, there is an urgent need for effective antibacterial strategies to treat infectious diseases. Current methods are often ineffective and require large amounts of hydrogen peroxide (H 2 O 2 ), with harmful effects on normal healthy tissue. Chemodynamic therapy (CDT) provides an ideal infection microenvironment (IME)-activated paradigm to tackle bacterial-related diseases. To take full advantage of the specificity of IME and enhanced CDT for wounds with bacterial infection, we have designed an intelligent antibacterial system that exploits nanocatalytic ZIF-67@Ag 2 O 2 nanosheets. In this system, silver peroxide nanoparticles (Ag 2 O 2 NPs) were grown on ultrathin zeolitic imidazolate framework-67 (ZIF-67) nanosheets by in situ oxidation, and then, ZIF-67@Ag 2 O 2 nanosheets with the ability to self-generate H 2 O 2 were triggered by the mildly acidic environment of IME. Lamellar ZIF-67 nanosheets were shown to rapidly degrade and release Co 2+, allowing the conversion of less reactive H 2 O 2 into the highly toxic reactive oxygen species hydroxyl radicals ( • OH) for enhanced CDT antibacterial properties. In vivo results revealed that the ZIF-67@Ag 2 O 2 nanosheet system exhibits excellent antibacterial performance against both Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli ) bacteria. The proposed hybrid strategy demonstrates a promising therapeutic strategy to enable antibacterial agents with IME-responsive nanocatalytic activity to circumvent antibiotic resistance against bacterial infections.