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CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

DOIFull Paper Access

20

Citations

37

References

2023

Year

Peiyao Zhang, Liting Bai, Yuanyuan Tong, Shengwen Guo, Wenlong Lu, Yue Yuan, Wenting Wang, Jin Yu, Peng Gao, Jinping Liu
Molecular Medicine

Abstract

Our findings indicated that CIRP may confer renoprotection against hypothermic IRI by suppressing PHD3/HIF-1α-mediated apoptosis. PHD3 inhibitors and HIF-1α stabilizers may have clinical value in renal IRI.

References

YearCitations

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