Radical bicyclization of 1,6-enynes with sulfonyl hydrazides by the use of TBAI/TBHP in the aqueous phase

Fa-Liang Liu, Mei Lan, Ling‐Tao Wang, Yu Zhou, Keqi Tang, Ting Li, Rongnan Yi, Wen‐Ting Wei

Chemical Communications · 2023 · 20 citations · 50 references

Concepts

Abstract

-butyl hydroperoxide (TBHP) combined system is reported. The resulting reaction of diverse nitrogen- and oxygen-polyheterocycles displays high chemical selectivity, high step-economy, and a moderate substrate scope. Moreover, iodosulfonylation can be realized by modulating the structure of the 1,6-enynes.

References

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