Concepedia

Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression

Jiuhui Xu, Qianyu Shi, Jingbing Lou, Boyang Wang, Wei Wang, Jianfang Niu, Lei Guo, Chenglong Chen, Yiyang Yu, Yi Huang,

Journal for ImmunoTherapy of Cancer · 2023 · 49 citations · 28 references

DOIFull text

Open access

Abstract

Our study implicates that the CCL5-CCR5 axis plays an important role in the malignant progression of chordoma and the regulation of macrophages, and that the CCL5-CCR5 axis is a potential therapeutic target in chordoma.

References

28

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Yonit Lavin, Soma Kobayashi, Andrew M. Leader et al. · Cell · 2017 · 1.2K citations · Full text

, , +11

An Immune Atlas of Clear Cell Renal Cell Carcinoma

Stéphane Chevrier, Jacob Levine, Vito Riccardo Tomaso Zanotelli et al. · Cell · 2017 · 1K citations · Full text

, , +5

Chordoma: incidence and survival patterns in the United States, 1973–1995

Mary L. McMaster, Alisa M. Goldstein, Christina M. Bromley et al. · Cancer Causes & Control · 2001 · 966 citations

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Luca Cassetta, Stamatina Fragkogianni, Andrew H. Sims et al. · Cancer Cell · 2019 · 922 citations · Full text

Building a global consensus approach to chordoma: a position paper from the medical and patient community

Silvia Stacchiotti, Josh Sommer · The Lancet Oncology · 2015 · 477 citations

, , +3