International Wound Journal · 2023 · 13 citations · 36 references
MedicineImmunologySurgeryBurn SurgeryClinical EpidemiologyImmunopathologyBurn CareBurn ManagementBurn PathophysiologyBurn ComplicationsBurn Injury EpidemiologyBurn Outcome AssessmentBurn Trauma CareImmunosuppression After Burn InjuryInflammatory Response In BurnsRetrospective Case Study
Patients with acute burns are more vulnerable to COVID-19 because of physiologically weak immune systems. This study aimed to assess and compare individual characteristics, clinical features, and clinical outcomes of acute burn among COVID-19 and non-COVID-19 patients. A retrospective study, with data collected from 611 acute burn patients with or without a COVID-19 diagnosis referred to a burn centre in Iran. Data were collected from April 2020 to 2021. The mean age of acute burns patients with COVID-19 was higher compared with acute burns patients with non-COVID-19 (47.82 vs. 32.59 years, P < .001). Acute burns occurred more frequently in COVID-19 patients with comorbidities compared with non-COVID-19 patients (48.72% vs. 26.92%, P = .003). 58.97% of COVID-19 patients and 55.42% of non-COVID-19 patients had grade II & III and II burns, respectively (P < .001). The mean total body surface area of the burn was higher in COVID-19 patients compared with non-COVID-19 patients (32.69% vs. 16.22%, P < .001). Hospitalisation in the intensive care unit (ICU) was higher in COVID-19 patients than in non-COVID-19 patients (76.92% vs. 15.73%, P < .001). Length of stay in hospital and ICU, the cost of hospitalisation, and waiting time for the operating room was higher in COVID-19 patients compared with non-COVID-19 patients (15.30 vs. 3.88 days, P < .001; 9.61 vs. 0.75 days, P < .001; 30 430 628.717 vs. 10 219 192.44 rials, P = .011; 0.84 vs. 0.24 min, P < .001, respectively). Intubation and mortality in-hospital were higher in COVID-19 patients compared with non-COVID-19 patients (41.02% vs. 6.99%, P < .001; 35.90% vs. 6.12%, P < .001, respectively). Therefore, it is recommended that health managers and policymakers develop a care plan to provide high-quality care to acute burns patients with COVID-19, especially in low-income countries.
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Re-epithelialization and immune cell behaviour in an ex vivo human skin model
Ana Rakita, Nenad Nikolić, Michael Mildner et al. · Scientific Reports · 2020 · 8.3K citations · Full text
Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
Sang Chul Lee, Kang Ju Son, Chang Hoon Han et al. · Scientific Reports · 2020 · 114 citations · Full text
Veterinary Medicine, Health Sciences, Infectious Diseases +15