Total Synthesis of (+)-Aberrarone

Abstract

The structurally intriguing diterpene (+)-aberrarone has been assembled in only 12 steps from the commercially available ( S, S )-carveol without protecting group manipulations. This concise synthesis features a Cu-catalyzed asymmetric hydroboration to generate the chiral methyl group, a Ni-catalyzed reductive coupling to link two fragments, and a Mn-mediated radical cascade cyclization to construct the triquinane system.