Concepedia

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways

Chen-Xi Xia, Alex Xiong Gao, Tina Ting-Xia Dong, Karl Wah Keung Tsim

Phytomedicine · 2023 · 33 citations · 19 references

DOIFull text

Open access

Abstract

Seabuckthorn flavonoids mimicked neurotrophic functions in inducing neuronal cell differentiation via activating PI3K/Akt and ERK pathways. The results suggest the beneficial functions of Seabuckthorn as a potential health food supplement in treating various brain disorders, e.g., neurodegenerative diseases.

References

19

Disruption of CREB function in brain leads to neurodegeneration

Theo Mantamadiotis, Thomas Lemberger, Susanne C. Bleckmann et al. · Nature Genetics · 2002 · 688 citations · Full text

, , +6

Pharmacokinetics and bioavailability of the flavonol quercetin in humans.

E.U. Graefe, Hartmut Derendorf, Markus Veit · PubMed · 1999 · 141 citations

, , +9

Radioprotection by a herbal preparation of Hippophae rhamnoides, RH-3, against whole body lethal irradiation in mice

Himanshu Goel, J. Prasad, Surinder Singh et al. · Phytomedicine · 2002 · 118 citations

, , +8

Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus

Yan Sun, Hailou Zhang, Zhangjie Wu et al. · ACS Chemical Neuroscience · 2021 · 106 citations

, , +26

Isorhamnetin, A Flavonol Aglycone from<i>Ginkgo biloba</i>L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor

Sherry L. Xu, Roy C.Y. Choi, Kevin Y. Zhu et al. · Evidence-based Complementary and Alternative Medicine · 2012 · 82 citations · Full text