Concepedia

Inhibition of TANK‐binding kinase1 attenuates the astrocyte‐mediated neuroinflammatory response through YAP signaling after spinal cord injury

Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu,

CNS Neuroscience & Therapeutics · 2023 · 10 citations · 40 references

DOIFull text

Open access

Abstract

TBK1-medicated innate immune pathway in astrocytes through YAP signaling plays an important role in the pathogenesis of SCI and inhibition of TBK1 may be a potential therapeutic drug for SCI.

References

40

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Valery L. Feigin, Emma Nichols, Marlena S. Bannick et al. · The Lancet Neurology · 2019 · 5.5K citations · Full text

Astrocyte scar formation aids central nervous system axon regeneration

Mark A. Anderson, Joshua E. Burda, Yilong Ren et al. · Nature · 2016 · 1.8K citations · Full text

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Siqi Liu, Xin Cai, Jiaxi Wu et al. · Science · 2015 · 1.8K citations

Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains

D. Michele Basso, Lesley C. Fisher, Aileen J. Anderson et al. · Journal of Neurotrauma · 2006 · 1.7K citations

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang, Guijun Shang, Xiang Gui et al. · Nature · 2019 · 985 citations

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