Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 18.1K citations · Full text

Life Sciences, Biochemistry, Cell Biology +10

Long‐term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma

Lee S. Rosen, David Gordon, Mary Kaminski et al. · Cancer · 2003 · 875 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +10

Cytochrome P450 oxidoreductase contributes tophospholipid peroxidation in ferroptosis

Yilong Zou, Haoxin Li, Emily Graham et al. · Nature Chemical Biology · 2020 · 705 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

Bo Yan, Youwei Ai, Qi Sun et al. · Molecular Cell · 2020 · 578 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Zoledronic Acid Significantly Reduces Skeletal Complications Compared With Placebo in Japanese Women With Bone Metastases From Breast Cancer: A Randomized, Placebo-Controlled Trial

Norio Kohno, Kenjiro Aogi, Hironobu Minami et al. · Journal of Clinical Oncology · 2005 · 545 citations

Medicine, Oncology, Pharmacotherapy +17