Concepedia

HFIP-promoted <i>para</i>-selective alkylation of anilines and phenols with tertiary alkyl bromides

Pengcheng Huang, Xipeng Jiang, Du Gao, Cheng Wang, Daqing Shi, Yingsheng Zhao

Organic Chemistry Frontiers · 2023 · 13 citations · 40 references

DOI

Abstract

We have herein reported a hexafluoroisopropanol-promoted para -selective Friedel–Crafts alkylation of arenes. Preliminary mechanistic studies revealed that the intramolecular hydrogen bond network of HFIP was the key factor in realizing site-selectivity.

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