Nitration of Pyrrolo[2,1-<i>a</i>]isoquinolines

Abstract

We have successfully modified a series of pyrrolo[2,1-<i>a</i>]isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu(NO₃)₂·H₂O, and Fe(NO₃)₃·9H₂O all can serve as effective nitrating reagents for functionalizing pyrrolo[2,1-<i>a</i>]isoquinolines. Various nitro-bearing pyrrolo[2,1-<i>a</i>]isoquinolines have been efficiently prepared in acceptable to good yields.