Batch and continuous flow asymmetric synthesis of anabolic-androgenic steroids <i>via</i> a single-cell biocatalytic Δ<sup>1</sup>-dehydrogenation and C17β-carbonyl reduction cascade

Yajiao Zhang, Minjie Liu, Zixin Yang, Juan Lin, Zedu Huang, Fen‐Er Chen

Green Chemistry · 2023 · 27 citations · 28 references

Concepts

Abstract

Asymmetric synthesis of (+)-boldenone and (+)-boldenone undecylenate was achieved in batch and continuous flow, using an enzyme cascade process catalyzed by an engineered Δ 1 -KstD and a mined 17β-CR.

References

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