Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K

Abstract

Herein, an efficient, scalable, and concise approach to an advanced pyrroloiminoquinone synthetic intermediate (<b>6b</b>) by way of a Larock indole synthesis is reported. The synthetic utility of this intermediate is demonstrated by its ready conversion to makaluvamines A (<b>1</b>) and K (<b>4</b>).