DICER1-associated central nervous system sarcoma: A comprehensive clinical and genomic characterization of case series of young adult patients

Abstract

DCS is an aggressive tumor with limited therapeutic options that requires a comprehensive diagnostic approach, including molecular characterization. Most cases had mutations in <i>TP53</i>, <i>NF1</i>, and <i>PTEN,</i> and most alterations at progression were related to <i>MAPK</i>, <i>RAS</i> and <i>PI3K</i> signaling pathways.