Concepedia

Publication | Open Access

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

DOIFull Paper Access

56

Citations

24

References

2023

Year

Lili Lian, Zhenmin Le, Zhenzhen Wang, Ying-ao Chen, Xiaodong Jiao, H. Jerry Qi, J. Fielding Hejtmancik, Xiaoyin Ma, Qinxiang Zheng, Yueping Ren
Investigative Ophthalmology & Visual Science

Abstract

The TXNIP/NLRP3 inflammasome pathway promotes HG-induced inflammation and HLEC pyroptosis, which is negatively regulated by SIRT1. This suggests viable strategies for treating diabetic cataract.

References

YearCitations

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