Psychomotor Stimulant Addiction: A Neural Systems Perspective

Abstract

The reinforcing (rewarding) effects of psychomotor stimulants (cocaine and amphetamine) depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens ([Wise, 1981][1]; for review, see[Koob, 1992][2]), perhaps especially the shell subregion ([Bassareo and Di Chiara, 1997][3]).