<i>In Vitro</i> Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation

Abstract

Staphylococcus aureus generates biofilms during many chronic human infections, which contributes to its growth and persistence in the host. Multiple genes and pathways necessary for S. aureus biofilm production have been identified, but knowledge is incomplete, and little is known about spontaneous mutations that increase biofilm formation as infection progresses.