Phase II Trial of Radio Frequency Ablation of Renal Cancer: Evaluation of the Kill Zone

Abstract

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 2002Phase II Trial of Radio Frequency Ablation of Renal Cancer: Evaluation of the Kill Zone BRIAN R. MATLAGA, RONALD J. ZAGORIA, RALPH D. WOODRUFF, FRANK M. TORTI, and M. CRAIG HALL BRIAN R. MATLAGABRIAN R. MATLAGA More articles by this author , RONALD J. ZAGORIARONALD J. ZAGORIA More articles by this author , RALPH D. WOODRUFFRALPH D. WOODRUFF More articles by this author , FRANK M. TORTIFRANK M. TORTI More articles by this author , and M. CRAIG HALLM. CRAIG HALL Financial interest and/or other relationship with Schering. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64154-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We report on the pathological evaluation of renal tumors after intraoperative radio frequency ablation performed immediately before surgical nephrectomy. Materials and Methods: Ten patients with renal tumors were enrolled in a prospective, Institutional Review Board approved phase II trial of radio frequency ablation. Following surgical exposure of the kidney a single 12-minute radio frequency ablation of the tumor was performed using the Radionics Cool-tip RF Radio Frequency Ablation System (Radionics, Burlington, Massachusetts). The tumor was then excised via radical or partial nephrectomy. Gross and histological evaluations of the tumor were performed, including evaluation with nicotinamide adenine dinucleotide vital staining. Results: All 10 tumors were confirmed histologically to be renal cell carcinoma. Mean tumor size was 3.2 cm. (range 1.4 to 8.0). Of the 10 tumors 8 were completely ablated with a mean treatment margin of 6.75 mm. (range 2 to 13). Of the 2 tumors that were incompletely treated 1 never attained a temperature sufficient for tissue destruction and the other measured 8 cm., far exceeding the expected ablation volume of treatment protocol. Conclusions: This study represents the initial report of the histological outcome of saline cooled radio frequency ablation of renal tumors. Our data indicate that it can completely destroy renal cancers while transmitting minimal collateral damage to surrounding renal parenchyma. Further investigation is required to determine long-term oncological outcome. References 1 : Cancer statistics, 2002. CA Cancer J Clin2002; 52: 23. Google Scholar 2 : The changing natural history of renal cell carcinoma. J Urol2001; 166: 1611. Link, Google Scholar 3 : Increased incidence of serendipitously discovered renal cell carcinoma. Urology1998; 51: 203. Google Scholar 4 : Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol2000; 163: 442. 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Google Scholar From the Departments of Urology, Radiology and Pathology, and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byHäcker A, Vallo S, Weiss C, Grobholz R, Stein T, Knoll T and Michel M (2018) Bipolar and Multipolar Radio Frequency Ablation With Resistance Controlled Power Output: Standardized Ex Vivo Kidney Tissue EvaluationJournal of Urology, VOL. 175, NO. 3, (1122-1126), Online publication date: 1-Mar-2006.JANZEN N, PERRY K, HAN K, KRISTO B, RAMAN S, SAID J, BELLDEGRUN A and SCHULAM P (2018) THE EFFECTS OF INTENTIONAL CRYOABLATION AND RADIO FREQUENCY ABLATION OF RENAL TISSUE INVOLVING THE COLLECTING SYSTEM IN A PORCINE MODELJournal of Urology, VOL. 173, NO. 4, (1368-1374), Online publication date: 1-Apr-2005.MABJEESH N, AVIDOR Y and MATZKIN H (2018) Emerging Nephron Sparing Treatments for Kidney Tumors: A Continuum of Modalities From Energy Ablation to Laparoscopic Partial NephrectomyJournal of Urology, VOL. 171, NO. 2, (553-560), Online publication date: 1-Feb-2004.HWANG J, WALTHER M, PAUTLER S, COLEMAN J, HVIZDA J, PETERSON J, LINEHAN W and WOOD B (2018) Radio Frequency Ablation of Small Renal Tumors: Intermediate ResultsJournal of Urology, VOL. 171, NO. 5, (1814-1818), Online publication date: 1-May-2004.MATSUMOTO E, WATUMULL L, JOHNSON D, OGAN K, TAYLOR G, JOSEPHS S and CADEDDU J (2018) THE RADIOGRAPHIC EVOLUTION OF RADIO FREQUENCY ABLATED RENAL TUMORSJournal of Urology, VOL. 172, NO. 1, (45-48), Online publication date: 1-Jul-2004.JOHNSON D, TAYLOR G, LOTAN Y, SAGALOWSKY A, KOENEMANN K and CADEDDU J (2018) The Effects of Radio Frequency Ablation on Renal Function and Blood PressureJournal of Urology, VOL. 170, NO. 6, (2234-2236), Online publication date: 1-Dec-2003. Volume 168Issue 6December 2002Page: 2401-2405 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordshyperthermia, inducedcarcinoma, renal cellMetricsAuthor Information BRIAN R. MATLAGA More articles by this author RONALD J. ZAGORIA More articles by this author RALPH D. WOODRUFF More articles by this author FRANK M. TORTI More articles by this author M. CRAIG HALL Financial interest and/or other relationship with Schering. More articles by this author Expand All Advertisement PDF downloadLoading ...