CYCLIN D1 PROTEIN OVEREXPRESSION IS RELATED TO TUMOR DIFFERENTIATION, BUT NOT TO TUMOR PROGRESSION OR PROLIFERATIVE ACTIVITY, IN TRANSITIONAL CELL CARCINOMA OF THE BLADDER

Abstract

No AccessJournal of UrologyInvestigative Urology1 Sep 1998CYCLIN D1 PROTEIN OVEREXPRESSION IS RELATED TO TUMOR DIFFERENTIATION, BUT NOT TO TUMOR PROGRESSION OR PROLIFERATIVE ACTIVITY, IN TRANSITIONAL CELL CARCINOMA OF THE BLADDER YUTAKA SUWA, YASUO TAKANO, MASAYUKI IKI, MITSUMASA TAKEDA, TOMOYUKI ASAKURA, SUMIO NOGUCHI, and MITSUNOBU MASUDA YUTAKA SUWAYUTAKA SUWA , YASUO TAKANOYASUO TAKANO , MASAYUKI IKIMASAYUKI IKI , MITSUMASA TAKEDAMITSUMASA TAKEDA , TOMOYUKI ASAKURATOMOYUKI ASAKURA , SUMIO NOGUCHISUMIO NOGUCHI , and MITSUNOBU MASUDAMITSUNOBU MASUDA View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62829-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We attempted to clarify the significance of cyclin D1 in the development and progression of transitional cell carcinoma of the bladder in humans. Materials and Methods: Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 163 patients was performed by the labeled streptavidin-biotin-peroxidase method. Results: Cyclin D1 protein overexpression was observed in 51 of the 163 specimens (31.3%). Cyclin D1 protein overexpression was showed a highly significant inverse correlation with the histological grade of malignancy (p <0.01). Grade 3 tumors showed a highly significant low incidence of cyclin D1 protein overexpression as compared with grade 2 tumors (p <0.01). There was no significant correlation between the overexpression of cyclin D1 protein and tumor stage or the Ki-67 labeling index. Conclusion: Cyclin D1 in transitional cell bladder carcinoma was closely related to tumor differentiation but not to tumor progression. Transitional cell carcinoma of the bladder may utilize another pathway for proliferation that is independent of cyclin D1. 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Volume 160Issue 3 Part 1September 1998Page: 897-900 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information YUTAKA SUWA More articles by this author YASUO TAKANO More articles by this author MASAYUKI IKI More articles by this author MITSUMASA TAKEDA More articles by this author TOMOYUKI ASAKURA More articles by this author SUMIO NOGUCHI More articles by this author MITSUNOBU MASUDA More articles by this author Expand All Advertisement PDF downloadLoading ...