Rapid screening of high‐priority <i>N</i> ‐nitrosamines in pharmaceutical, forensic, and environmental samples with paper spray ionization and filter cone spray ionization‐mass spectrometry

Abstract

PSI-MS and FCSI-MS were successful in detecting trace-level NAMS in complex liquid- and solid-phase matrices with little to no prior preparation. This work suggests that these methodologies can provide a means for assessing problematic pharmaceutical adulterants/degradants for expedited quality control, as well as enhancing environmental stewardship efforts and forensic investigations.