Homology-directed repair of an MYBPC3 gene mutation in a rat model of hypertrophic cardiomyopathy

Evidence for Cardiomyocyte Renewal in Humans

Olaf Bergmann, Ratan D. Bhardwaj, Samuel Bernard et al. · Science · 2009 · 3.1K citations · Full text

Life Sciences, Cardiology, Cell Biology +9

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Manuel Stemmer, Thomas Thumberger, Maria del Sol Keyer et al. · PLoS ONE · 2015 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

Chengzu Long, Leonela Amoasii, Alex A. Mireault et al. · Science · 2015 · 935 citations

Life Sciences, Genetics, Molecular Biology +17

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

Kunwoo Lee, Michael J. Conboy, Hyo Min Park et al. · Nature Biomedical Engineering · 2017 · 747 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

Yang Yang, Lili Wang, Peter Bell et al. · Nature Biotechnology · 2016 · 555 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +15