Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.4K citations · Full text

Inflammation, Host Response, Molecular Immunology +9

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Jiaxi Wu, Lijun Sun, Xiang Chen et al. · Science · 2012 · 2.4K citations

Microbial Pathogens, Molecular Regulation, Innate Immune System +24

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Ryan D. Michalek, Valerie A. Gerriets, Sarah R. Jacobs et al. · The Journal of Immunology · 2011 · 2K citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +20

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Gerritje J. W. van der Windt, Bart Everts, Chih‐Hao Chang et al. · Immunity · 2011 · 1.5K citations · Full text

Immunological Memory, Mitochondrial Function, Organelle Dynamic +10

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Xiang Gui, Hui Yang, Tuo Li et al. · Nature · 2019 · 1.2K citations · Full text

Mitophagy, Cellular Physiology, Cell Autophagy +16