Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

Haipeng Liu, Haiping Zhang, Xiangyang Wu, +32

Nature

ChromatinGenome InstabilityChromatin RemodelingNuclear OrganizationPromotes Tumorigenesis +3

Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA

Bo Yang, Jie Wang, Yanming Wang, +4

The Journal of Immunology

Viral ReplicationTripartite MotifImmunologyMolecular BiologyInnate Immunity +17

Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

Lin Wang, Juehui Wu, Jun Li, +16

Nature

Host ResponseImmunologyMycobacterial ProteinMicrobiologyHost-microbe Interaction +2

RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation

Bo Yang, Yue Liu, Yuhan Cui, +8

PLoS Pathogens

Adaptive Immune SystemInnate Immune SystemImmunologyImmunologic MechanismInnate Immunity +15

Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions

Pranab K. Mukherjee, Quang Tam Nguyen, Jiannan Li, +33

Gastroenterology

InflammationChronic Inflammatory DiseasesSystems BiologyIntercellular InteractionsSingle Cell Sequencing +6

Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn’s disease

Ren Mao, Geneviève Doyon, Ilyssa O. Gordon, +17

Gut

Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7

Yu Hu, Jie Wang, Bo Yang, +8

The Journal of Immunology

Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7

Jie Wang, Bo Yang, Yu Hu, +10

The Journal of Immunology

ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1

Zhenhu Li, Yuan Zhang, Zhiduo Liu, +12

Nature Immunology

Signal TransductionCell RegulationTh2 Cell EgressCell InteractionImmunology +7

Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation

Mutian Jia, Yuanyuan Wang, Jie Wang, +8

Nature Communications