Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis

Abstract

Our study confirmed metformin could not only improve body weight and metabolism disorders, but also improve ovarian dysfunction in PCOS mice.In addition, we explored metformin could regulate ferroptosis to improve PCOS <i>via</i> the SIRT3/AMPK/mTOR pathway. Our study complements the mechanisms by which metformin improves PCOS.