Concepedia

N-Glycosylation of Rotavirus NSP4 Protein Affects Viral Replication and Pathogenesis

Jeffery A. Nurdin, Tomohiro Kotaki, Takahiro Kawagishi, Shintaro Sato, Moeko Yamasaki, Ryotaro Nouda, Shohei Minami, Yuta Kanai, Takeshi Kobayashi

Journal of Virology · 2023 · 25 citations · 48 references

DOIFull text

Open access

Concepts

Abstract

Rotavirus is the main cause of gastroenteritis in young children and infants worldwide, contributing to 128,500 deaths each year. Here, we used a reverse genetics approach to examine the role of NSP4 N-glycosylation.

References

48

Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

Shabir A. Madhi, Nigel A. Cunliffe, A. Duncan Steele et al. · New England Journal of Medicine · 2010 · 909 citations · Full text

, , +16

Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years

Christopher Troeger, Puja C Rao, Shujin Cao et al. · JAMA Pediatrics · 2018 · 871 citations · Full text

, , +17

Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial

John C. Victor, Michael J. Dallas, Michele L. Coia et al. · The Lancet · 2010 · 832 citations

, , +16

Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial

George Armah, Samba O. Sow, Robert F. Breiman et al. · The Lancet · 2010 · 663 citations

, , +17

SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

Juan A. Pérez-Bermejo, Sarah J. Rockwood, Camille R. Simoneau et al. · Science Translational Medicine · 2021 · 258 citations · Full text

, , +13