Publication | Open Access
Rabbit Secretory IgA: Identification and Genetic Control of Two Allotypes of Secretory Component
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1974
Year
Protein SecretionLaboratory ImmunologyGeneticsImmunodeficienciesImmunologyImmune RegulationImmunodominanceAntigen ProcessingMolecular GeneticsSecretory IgaImmune SystemImmunogeneticsSecretory GranulesSecretory PathwayCell SignalingSecretory ComponentAllergyRabbit Secretory IgaAutoimmunityHumoral ImmunityImmune FunctionAntibody BiologyBiologyMolecular ImmunologyGenetic ControlPathogenesisImmunoglobulin EAbstract TwoMedicineCell Development
Abstract Two allotypes of rabbit secretory IgA have been identified with antisera obtained by cross-immunization of rabbits with secretory IgA. The two antisera, anti-t61 and anti-t62, each reacted by double diffusion analysis with secretory IgA from some but not all rabbits. Both anti-t61 and anti-t62 reacted with purified free secretory component obtained from whey. Thus, anti-t61 and anti-t62 are identifying allotypic specificities on secretory component. Genetic studies revealed that t61 and t62 are controlled by allelic genes at an autosomal locus. The t locus is not closely linked to the VHa, Cαf and Cαg (heavy chain) loci nor to the b (light chain) locus of immunoglobulins.