Optimizing maximum resection of glioblastoma: Raman spectroscopy versus 5-aminolevulinic acid

Abstract

According to the study data, RS is capable of detecting tumor-infiltrated brain with higher sensitivity but lower specificity than the current standard of 5-ALA. With further technological and workflow advancements, RS in combination with protoporphyrin IX fluorescence may contribute to pathology-tailored glioma resection in the future.