Organic Letters · 2022 · 18 citations · 15 references
Natural SciencesBiochemistryChemistryCoral Reef BiologyMarine Invertebrate BiologyOrganic ChemistryMarine Bioactive CompoundsMarine Natural Product BiosynthesisMarine Natural ProductsReef-building CoralsTerpenoid BiosynthesisAnti-inflammatory ActivityAnti-inflammatory MechanismsBioactive Compounds From Marine CoralsBiosynthetic Pathways Of Marine Natural ProductsMarine TerpenoidsMarine-derived Anti-inflammatory CompoundsSoft Coral BiologySoft Coral Metabolites
Five new furanobutenolide-derived C19-norcembranoid diterpenes, sinudenoids A–E (1–5, respectively), were isolated from the soft coral Sinularia densa. Sinudenoid A (1) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B–D (2–4, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E (5) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1–6 is proposed. Compound 5 exhibits strong anti-inflammatory activity in the zebrafish model.
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Fábio Luiz Paranhos Costa, Ana Carolina Ferreira de Albuquerque, Rodolfo G. Fiorot et al. · Organic Chemistry Frontiers · 2021 · 97 citations