Targeting TBK1 attenuates ocular inflammation in uveitis by antagonizing NF-κB signaling

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

Life Sciences, Immunology, Molecular Biology +16

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.5K citations · Full text

Life Sciences, Cell Biology, Immunology +12

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Siqi Liu, Xin Cai, Jiaxi Wu et al. · Science · 2015 · 1.9K citations

Life Sciences, Immunology, Molecular Biology +17

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Edward A. Miao, Irina A. Leaf, Piper M. Treuting et al. · Nature Immunology · 2010 · 1.3K citations · Full text

Life Sciences, Immunology, Microbiology +16

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang, Guijun Shang, Xiang Gui et al. · Nature · 2019 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +12