A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao, +9

Science Translational Medicine

Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau, Igor Smirnov, Timothy Keyes, +9

Nature

EpendymaLymphatic SystemNeurologyNeuropathologyCapillary Network +14

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim, +10

Science

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aleksanteri Aspelund, Salli Antila, Steven T. Proulx, +5

The Journal of Experimental Medicine

Brain Interstitial FluidEpendymaCerebrospinal FluidLymphatic SystemNeurology +16

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

Sandro Dá Mesquita, Antoine Louveau, Andrea Vaccari, +20

Nature

Alzheimer's DiseaseFunctional AspectsLymphatic SystemDegenerative PathologyNeurology +4

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Ping Shen, Toralf Roch, Vicky Lampropoulou, +28

Nature

InflammationCritical RegulatorsAutoimmune DiseaseIl-35-producing B CellsHumoral Response +8

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

David Gate, Naresha Saligrama, Olivia Leventhal, +18

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseCd8 T CellsMedicineCerebrospinal Fluid +9

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

Antoine Louveau, Jasmin Herz, Maria Nordheim Alme, +18

Nature Neuroscience

NeuroanatomyMedicineCerebrospinal FluidImmunologyLymphatic System +10

IL-35-mediated induction of a potent regulatory T cell population

Lauren W. Collison, Vandana Chaturvedi, Abigail Henderson, +13

Nature Immunology

Il-35-mediated InductionAutoimmune DiseaseT-regulatory CellImmunologySelf-tolerance +4

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Noel Derecki, Amber Cardani, Chun Yang, +4

The Journal of Experimental Medicine

Key RoleIl-4-producing T CellsAdaptive Immune SystemT-regulatory CellImmunology +16