Morphine mediated neutrophil infiltration in intestinal tissue play essential role in histological damage and microbial dysbiosis

Abstract

. Taken together, we provide the first direct evidence that neutrophil infiltration contributes to morphine-induced intestinal tissue damage and gut microbial dysbiosis. Our findings implicate that inhibition of neutrophil infiltration may provide therapeutic benefits against gastrointestinal dysfunctions associated with opioid use.