Concepedia

Publication | Open Access

MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis

DOIFull Paper Access

95

Citations

45

References

2022

Year

Cheng‐Kai Wang, Tzu-Jou Chen, Grace Y.T. Tan, Fang‐Pei Chang, Samyuktha Sridharan, Chen-Hsin Albert Yu, Yen‐Hou Chang, Yi‐Jen Chen, Li-Tzu Cheng, Wendy W. Hwang‐Verslues
Cancer Research

Abstract

Degradation of p53 mediated by MEX3A drives ovarian cancer growth by circumventing p53 tumor suppressive functions, suggesting targeting MEX3A as a potential strategy for treating of ovarian cancer expressing WT p53.

References

YearCitations

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