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Publication | Open Access

Spatiotemporal Control of Vascular Ca <sub>V</sub> 1.2 by α1 <sub>C</sub> S1928 Phosphorylation

DOIFull Paper Access

27

Citations

50

References

2022

Year

Miguel Martín‐Aragón Baudel, Víctor A. Flores-Tamez, Junyoung Hong, Gopyreddy R. Reddy, Pauline Maillard, Abby E. Burns, Kwun Nok Mimi Man, Kent C. Sasse, Sean M. Ward, William A. Catterall,
Circulation Research

Abstract

These results suggest that PKA-dependent S1928 phosphorylation promotes the spatial reorganization of vascular α1<sub>C</sub> into "superclusters" upon hyperglycemia and diabetes. This triggers Ca<sub>V</sub>1.2 activity and cooperativity, directly impacting vascular reactivity. The results may lay the foundation for developing therapeutics to correct Ca<sub>V</sub>1.2 and arterial function during diabetic hyperglycemia.

References

YearCitations

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