Facile One-Pot Synthesis of Meteor Hammer-like Au-MnO_<i>x</i> Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination

Abstract

Inspired by the effective interfacial interactions between natural creatures (e.g., cockleburs and viruses) and their bio-hosts, we developed a novel gold-manganese oxide nanoparticle (Au-MnOx) nanoenzyme with a spiky surface for NIR-II light-induced synergistic antibacterial therapy. Au-MnOx with favorable photothermal performance and peroxidase-like activity could achieve combined photothermal therapy (PTT)/chemodynamic therapy (CDT) under NIR-II irradiation with a low concentration. Of special note, the spiky surface endows Au-MnOx robust bacterial adhesion, in turn favoring the following synergistic PTT/CDT through effective interaction between Au-MnOx and bacteria. In vitro results display that our combined antibacterial nanoplatforms possess the broad-spectrum antibacterial ability against both Escherichia coli (E. coli, Gram-negative) and Staphylococcus aureus (S. aureus, Gram-positive). Moreover, satisfactory in vivo bactericidal efficacy and good cytocompatibility could be obtained in the rat wound model with the mixed bacterial infections. This study puts forward a facile one-pot method to establish the well-designed Au-MnOx nanozymes with a spiky surface for NIR-II light-enhanced bacterial elimination. The meteor hammer-like Au-MnOx holds great potential in construction of a novel antibacterial treatment system to settle the overuse of antibiotics.