Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a <scp>JAK1</scp>/<scp>JAK2</scp> inhibitor

Abstract

A JAK1/JAK2 inhibitor can prevent and reverse anti-PD-L1-induced diabetes by blocking IFNγ and γc cytokine activities. Our study provides preclinical validation of JAK1/JAK2 inhibitor use in checkpoint inhibitor-induced diabetes.