STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade

Publication | Open Access

DOI Full Paper Access

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References

2022

Year

Yaara Ofir-Rosenfeld, L. Vasiliauskaitė, C. Saunders, A. Sapetschnig, G. Tsagkogeorga, M. Albertella, M. Carkill, J. Self-Fordham, J.B. Holz, O. Rausch

European Journal of Cancer

Cancer ImmunosurveillanceTumour GrowthImmunologyTumor ImmunityRna Methyltransferase Mettl3Immune Checkpoint InhibitorIncreased Interferon SignallingTumor SuppressorImmunotherapyMedicineCell BiologyTumor MicroenvironmentCancer Research