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Publication | Open Access

KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer

DOIFull Paper Access

42

Citations

38

References

2022

Year

Jing Yang, Lin Jin, Hong Sun Kim, Feng Tian, Zhujun Yi, Karan Bedi, Mats Ljungman, Marina Pasca di Magliano, Howard C. Crawford, Jiaqi Shi
Cancer Research

Abstract

KDM6A loss in pancreatic cancer cells alters the immune microenvironment by increasing CXCL1 secretion and neutrophil recruitment, providing a rationale for targeting the CXCL1-CXCR2 signaling axis in tumors with low KDM6A.

References

YearCitations

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