Concepedia

Targeting tumour-intrinsic N <sup>7</sup> -methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

Hai‐Ning Liu, Xuezhen Zeng, Xuxin Ren, Yifan Zhang, Manling Huang, Li Tan, Zihao Dai, Jiaming Lai, Wenxuan Xie, Zebin Chen,

Gut · 2022 · 72 citations · 32 references

DOI

Abstract

Our data uncover novel mechanisms underlying chemokine regulation and TIME shaping at the layer of messenger RNA translation level and provide new insights for development of efficient cancer immunotherapeutic strategies.

References

32

TIMER2.0 for analysis of tumor-infiltrating immune cells

Taiwen Li, Jingxin Fu, Zexian Zeng et al. · Nucleic Acids Research · 2020 · 5.5K citations · Full text

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

Robert L. Ferris, George R. Blumenschein, Jérôme Fayette et al. · New England Journal of Medicine · 2016 · 4.9K citations · Full text

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

Jonathan E. Rosenberg, Jean Hoffman‐Censits, Tom Powles et al. · The Lancet · 2016 · 3.7K citations · Full text

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang, Boxuan Zhao, Ian A. Roundtree et al. · Cell · 2015 · 3.5K citations · Full text

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Proteogenomic characterization of human colon and rectal cancer

Nature · 2014 · 1.5K citations

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