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A novel cascade signal amplification strategy integrating CRISPR/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids

EngineeringGenome SurgeryMedicineDisease-related Nucleic AcidsSpecific Sers DetectionGenetic EngineeringDna ReplicationMolecular BiologySynthetic BiologyNucleic Acid AmplificationGenome EngineeringGene EditingCrisprSystems BiologyMolecular DiagnosticsOff-target EffectGenome EditingHybridization Chain Reaction