Concepedia

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Ahmed B. Montaser, Janita Kuiri, Teemu Natunen, Pavel Hruška, David Potěšil, Seppo Auriola, Mikko Hiltunen, Tetsuya Terasaki, Marko Lehtonen, Aaro J. Jalkanen,

Life Sciences · 2022 · 10 citations · 44 references

DOIFull text

Open access

Abstract

The efficacy of NSAIDs can be improved via the utilization of LAT1 and repurposed for the treatment of neuroinflammation. This improved brain delivery and microglia localisation can be applied to other inflammatory modulators to achieve effective and targeted CNS therapies.

References

44

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

Damian Szklarczyk, Annika L. Gable, Katerina Nastou et al. · Nucleic Acids Research · 2020 · 8.2K citations · Full text

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Pérez‐Riverol, Attila Csordás, Jingwen Bai et al. · Nucleic Acids Research · 2018 · 7.2K citations · Full text

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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

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DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput

Vadim Demichev, Christoph B. Messner, Spyros I. Vernardis et al. · Nature Methods · 2019 · 3K citations · Full text

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Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

Yasuo Uchida, Sumio Ohtsuki, Yuki Katsukura et al. · Journal of Neurochemistry · 2011 · 891 citations

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