Concepedia

Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia

Indira Singaram, Ashutosh Sharma, Shashank Pant, Muyun Lihan, Mi-Jeong Park, Melissa R. Pergande, Pawanthi Buwaneka, Yusi Hu, Nadim Mahmud, You‐Me Kim,

Nature Chemical Biology · 2022 · 27 citations · 29 references

Open access

Concepts

MedicineOncologyPharmacologyCell SignalingMolecular OncologyMolecular PharmacologyLipid-protein InteractionsProtein-lipid InteractionsReceptor Tyrosine Kinase SignalingTargeted Cancer TherapyTargeted TherapyTyrosine Kinase InhibitorsAcute Myeloid Leukemia BiologyAcute Myeloid Leukemia TherapyAcute Myeloid Leukemia TreatmentMembrane Targeting By Lipid BindingSyk Kinase Signaling

References

29

Scalable molecular dynamics with NAMD

J. C. Phillips, Rosemary Braun, Wei Wang et al. · Journal of Computational Chemistry · 2005 · 17.4K citations · Full text

Natural Sciences, Chemistry, High-performance Computing +17

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry · 2006 · 6.9K citations

Pharmacy, Medicinal Chemistry, Computational Chemistry +16

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

G. Madhavi Sastry, Matvey Adzhigirey, Tyler Day et al. · Journal of Computer-Aided Molecular Design · 2013 · 6K citations

Life Sciences, Biochemistry, Bioinformatics +14

Identifying and Characterizing Binding Sites and Assessing Druggability

Thomas A. Halgren · Journal of Chemical Information and Modeling · 2009 · 1.8K citations

Pharmacy, Bioinformatics, Pharmacology +13