Peyronie's Disease is Associated with an HLA Class II Antigen, HLA-DQ5, Implying an Autoimmune Etiology

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Oct 1996Peyronie's Disease is Associated with an HLA Class II Antigen, HLA-DQ5, Implying an Autoimmune Etiology Daniel A. Nachtsheim and Ann Rearden Daniel A. NachtsheimDaniel A. Nachtsheim and Ann ReardenAnn Rearden View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65579-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Previous studies using serological (protein based) HLA typing methods suggested an association between various HLA antigens and Peyronie's disease. We used a molecular (deoxyribonucleic acid based) HLA typing method to determine whether Peyronie's disease is associated with class II HLA antigens. Materials and Methods: Class II HLA typing using the polymerase chain reaction-sequence specific primer method was performed in 31 patients with Peyronie's disease, 19 age matched urological patients with disorders other than Peyronie's disease and 75 major organ donor cadavers representative of the general population. Results: The frequency of HLA-DQ5 was significantly increased in patients with Peyronie's disease (61 percent HLA-DQ5 positive) compared to age matched disease-free controls (11 percent HLA-DQ5 positive, corrected p = 0.003) and general population controls (25 percent HLA-DQ5 positive, corrected p = 0.005). The relative risk for Peyronie's disease associated with HLA-DQ5 was 12.7 and 4.6 compared to age matched and general population controls, respectively. Conclusions: This study shows a positive association for the HLA class II antigen HLA-DQ5 with Peyronie's disease, suggesting that HLA-DQ5 is a risk factor for Peyronie's disease and implying an autoimmune etiology for this disorder. References 1 : HLA-DQ associations with autoimmune disease. Autoimmunity1992; 14: 79. Google Scholar 2 : HLA molecules in autoimmune diseases. Clin. Biochem.1992; 25: 187. Google Scholar 3 : MHC class-II molecules and autoimmunity. Ann. Rev. Immunol.1991; 9: 493. Google Scholar 4 : Role of HLA genes in predisposition to develop insulin-dependent diabetes mellitus. Ann. Med.1992; 24: 523. Google Scholar 5 : HLA association of idiopathic Peyronie's disease: an indication of autoimmune phenomena in etiopathogenesis?. Tissue Antigens1991; 38: 104. Google Scholar 6 : The association of histocompability antigens of the B7 cross-reacting group with Peyronie's disease. J. Urol.1979; 122: 34. Abstract, Google Scholar 7 : Identification of an inherited form of Peyronie's disease with autosomal dominant inheritance and association with Dupuytren's contracture and histocompatibility B7 cross-reacting antigens. J. Urol.1982; 128: 48. Link, Google Scholar 8 : The association of Peyronie's disease with HLA B7 cross-reactive antigens. A case report of identical twins. Cleveland Clin. J. Med.1987; 54: 427. Google Scholar 9 : HLA-A and B antigens in patients with Peyronie's disease. Urology1984; 23: 547. Google Scholar 10 : Non-association of Peyronie's disease with HLA B7 cross-reactive antigens. J. Urol.1982; 127: 1223. Link, Google Scholar 11 : HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens1992; 39: 225. Google Scholar 12 : A fast PCR-SSP method for HLA-DQ generic typing. Tissue Antigens1993; 41: 102. Google Scholar 13 : Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J. Immunol.1992; 148: 249. Google Scholar 14 : Detection of novel sequence heterogeneity and haplotypic diversity of HLA class II genes. Immunogenetics1991; 33: 374. Google Scholar 15 : The estimating and significance of the logarithm of a ratio of frequencies. Ann. Hum. Genet.1955; 20: 309. Google Scholar 16 : On estimating the relation between blood group and disease. Ann. Hum. Genet.1955; 19: 251. Google Scholar 17 : The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984. J. Urol.1991; 146: 1007. Link, Google Scholar 18 : Genetic factors in the etiology and pathogenesis of autoimmunity. FASEB J.1992; 6: 2800. Google Scholar 19 : Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response. Clin. Immunol. Immunopath.1994; 73: 275. Google Scholar 20 : Apoptosis and disease. Lancet1993; 341: 1251. Google Scholar 21 : Ageing and genetic control of immune responsiveness. Immunol. Lett.1994; 40: 231. Google Scholar 22 : Thymus function, ageing and autoimmunity. Immunol. Lett.1994; 40: 225. Google Scholar 23 : Infection and molecular mimicry in autoimmune diseases of childhood. Clin. Exp. Rheumatol.1994; 12: S35. Google Scholar 24 : Stress proteins, autoimmunity, and autoimmune disease. Curr. Top. Microbiol. Immunol.1991; 167: 161. Google Scholar 25 : Increased serum levels of anti-elastin antibodies in patients with Peyronie's disease. J. Urol.1994; 152: 105. Abstract, Google Scholar 26 : Dupuytren's disease. West. J. Med.1990; 152: 430. Google Scholar 27 : Epidemiological and structural findings supporting the fibromatous origin of dorsal knuckle pads. J. Hand Surg.1991; 16: 258. Google Scholar 28 : Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin. Immunol. Immunopath.1994; 72: 283. Google Scholar 29 : Growth factors. Local and systemic. Arch. Surg.1993; 128: 1227. Google Scholar 30 : Growth factors and wound healing: biochemical properties of growth factors and their receptors. Amer. J. Surg.1993; 165: 728. Google Scholar 31 : Fibroblast growth factors, proteins with a broad spectrum of biological activities. Neurol. Res.1994; 16: 313. Google Scholar 32 : Increased induction of HLA-DR by interferon-gamma in cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial dermopathy. J. Clin. Endocr. Metab.1991; 73: 307. Google Scholar 33 : Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science1995; 268: 1343. Google Scholar 34 : Connective tissue metabolism including cytokines in sclerderma. Curr. Opin. Rheumatol.1993; 5: 766. Google Scholar 35 : Intralesional verapamil injection for the treatment of Peyronie's disease. J. Urol.1994; 151: 1522. Abstract, Google Scholar 36 : Autoimmune disease. A problem of defective apoptosis. Arthritis Rheum.1994; 37: 1415. Google Scholar 37 : Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. Proc. Soc. Exp. Biol. Med.1994; 207: 129. Google Scholar 38 : Treatment of autoimmune diseases and systemic vasculitis with pooled human intravenous immune globulin. Clin. Exp. Immunol.1994; 97: 31. Google Scholar 39 : Competitive inhibition of antigen presentation in animal models of autoimmune disease. Sem. Immunol.1991; 3: 247. Google Scholar Department of Surgery, Scripps Clinic and Research Foundation and Department of Pathology, University of California San Diego, La Jolla, California.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMULHALL J, BRANCH J, LUBRANO T and SHANKEY T (2018) Radiation Increases Fibrogenic Cytokine Expression by Peyronie's Disease FibroblastsJournal of Urology, VOL. 170, NO. 1, (281-284), Online publication date: 1-Jul-2003.HAUCK E, HAUPTMANN A, WEIDNER W, BEIN G and HACKSTEIN H (2018) Prospective Analysis of HLA Classes I and II Antigen Frequency in Patients With Peyronie's DiseaseJournal of Urology, VOL. 170, NO. 4 Part 1, (1443-1446), Online publication date: 1-Oct-2003.MIURA H, TSUJIMURA A, NISHIMURA K, KITAMURA M, KONDOH N, TAKEYAMA M, FUJIOKA H, SADA M, TSUJI T, MATSUMIYA K, TAKAHARA S and OKUYAMA A (2018) SUSCEPTIBILITY TO IDIOPATHIC AZOOSPERMIA IN JAPANESE MEN IS LINKED TO HLA CLASS I ANTIGENJournal of Urology, VOL. 159, NO. 6, (1939-1941), Online publication date: 1-Jun-1998.Jarow J and Lowe F (2018) PENILE TRAUMA: AN ETIOLOGIC FACTOR IN PEYRONIE'S DISEASE AND ERECTILE DYSFUNCTIONJournal of Urology, VOL. 158, NO. 4, (1388-1390), Online publication date: 1-Oct-1997. Volume 156Issue 4October 1996Page: 1330-1334 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Daniel A. Nachtsheim More articles by this author Ann Rearden More articles by this author Expand All Advertisement PDF downloadLoading ...